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林树海

日期:2014-05-29 来源:huanke 浏览:956
林树海博士本科毕业于广州中医药大学中药学专业,硕士毕业于中山大学药物分析专业,博士毕业于香港浸会大学分析化学专业;曾获得德国学术交流中心(DAAD)资助到慕尼黑赫姆霍兹中心做访问学者,后任香港浸会大学化学系研究助理教授,现任杜克-新加坡国立大学医学研究院资深研究员。

电子邮箱: linroseshuhai@gmail.com

研究方向 
代谢组学,环境毒理与代谢,肿瘤代谢
应用质谱建立代谢组学分析方法,分析人或动物暴露于环境污染物之后的代谢表型改变,从而探寻其代谢机制。代谢组学与同位素标记技术相结合,建立代谢流分析方法,可应用于肿瘤代谢研究,阐明肿瘤细胞与正常体细胞的代谢差异。
现招硕士研究生两名,从事芳香烃受体的构效关系研究与肿瘤代谢研究。

代表性科研论文
1.S. Lin*, B. Kanawati*, L. Liu, M. Witting, M. Li, J. Huang, P. Schmitt-Kopplin, Z. Cai, "Ultrahigh resolution mass spectrometry-based metabolic characterization reveals cerebellum as a disturbed region in two animal models", Talanta, 118(1), 45-53 (2014) (The single asterisk indicates co-first authors). 
2.S. Lin, H. Liu, B. Kanawati, L. Liu, J. Dong, M. Li, J. Huang, P. Schmitt-Kopplin, Z. Cai, "Hippocampal metabolomics using ultrahigh-resolution mass spectrometry reveals neuroinflammation from Alzheimer's disease in CRND8 mice", Anal Bioanal Chem., 405(15), 5105-17 (2013).
3.S. Lin, Z. Yang, H. Liu, L. Tang, Z. Cai, "Beyond glucose: Metabolic shifts in responses to the effects of the oral glucose tolerance test and the high-fructose diet in rats", Mol. Biosyst., 7(5):1537-48 (2011).
4.S. Lin, Z. Yang, H. Liu, Z. Cai, "Metabolomic Analysis of Liver and Skeletal Muscle Tissues in C57BL/6J and DBA/2J Mice Exposed to 2,3,7,8- Tetrachlorodibenzo-p-Dioxin", Mol. Biosyst., 7(6), 1956-65 (2011).
5.S. Lin, Z. Yang, X. Zhang, Z. Bian, Z. Cai, "Hippocampal Metabolomics Reveals 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Toxicity Associated with Ageing in Sprague-Dawley Rats", Talanta, 85(2), 1007-12 (2011).
6.S. Lin, N. Liu, Z. Yang, W. Song, P. Wang, H. Chen, M. Lucio, P. Schmitt-Kopplin, G. Chen, Z. Cai, "GC/MS-based metabolomics reveals fatty acid biosynthesis and cholesterol metabolism in cell lines infected with influenza A virus", Talanta; 83(1), 262-8 (2010).
7.S. Lin*, W. Chan*, Z. Cai, "Liquid chromatography/mass spectrometry for investigating the biochemical effects induced by aristolochic acid in rats: the plasma metabolome", Rapid Commnun. Mass Spectrom.,24(9), 1312-8 (2010) (The single asterisk indicates co-first authors).
8.S. Lin, Z. Yang, Y. Shen Y, Z. Cai, "LC/MS-based non-targeted metabolomics for the investigation of general toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J and DBA/2J mice", Int. J. Mass Spectrom.; 301(1-3), 29-36 (2011) (Michael L. Gross 70th Birthday Honor Issue).
9.W. Chan*, S. Lin*, S. Sun, H. Liu, Z. Cai, J. Luk, "Metabolomics analysis of the responses to partial hepatectomy in hepatocellular carcinoma patients", Am J Anal Chem., 2, 142-151 (2011) (The single asterisk indicates co-first authors).
10.S. Lin, D. Wang, D. Yang, J. Yao, Y. Tong, J. Chen, "Characterization of steroidal saponins in crude extract from Dioscorea nipponica Makino by liquid chromatography tandem multi-stage mass spectrometry", Anal Chim Acta., 599(1), 98-106 (2007).